Poliforce

Introducing POLIFORCE-2, the next-generation non-steroidal anti-inflammatory drug (NSAID) for osteoarthritis.

Welcome to Intra Life Private Limited, the leading provider of innovative healthcare solutions. We are proud to introduce POLIFORCE-2 Polmacoxib 2mg Capsules, the next generation non-steroidal anti-inflammatory drug specifically designed to provide effective pain relief for Osteoarthritis (OA) patients.

POLIFORCE-2 is a once-daily capsule that provides rapid relief from pain and inflammation, while also preserving the integrity of your gastrointestinal (GI) and cardiovascular (CV) systems.

POLIFORCE-2 Polmacoxib 2mg Capsules have revolutionized the treatment of OA by offering a unique combination of benefits. With a small dose and high potency, our product ensures better safety for patients. Its long half-life increases persistence, surpassing conventional anti-inflammatory analgesics in efficacy. In fact, POLIFORCE-2 has demonstrated superior SGA (Subject's Global Assessment) and PGA (Physicians Global Assessment) scores compared to celecoxib.

One of the key advantages of POLIFORCE-2 is its exceptional safety profile, especially in terms of gastrointestinal (GI) safety compared to traditional NSAIDs for OA. Our research has shown that a 2mg dose of Polmacoxib is as effective as the clinically recommended 200mg dose of celecoxib. By offering the lowest effective dose of 2mg/day OD, POLIFORCE-2 ensures optimal efficacy while minimizing the risk of adverse effects associated with traditional NSAIDs.

POLIFORCE-2 Capsules contain Polmacoxib, the first tissue-specific once-a-day osteoarthritis drug with a novel dual mode of action. It effectively inhibits COX-2 and binds to carbonic anhydrase with high affinity. By specifically targeting the affected joints, POLIFORCE-2 restores mobility while preserving the integrity and safety of the GI and cardiovascular (CV) systems.

Our product delivers rapid relief from OA signs and symptoms, with a faster onset of action compared to celecoxib. In clinical trials, patients treated with Polmacoxib reported their condition as "Much Improved" or "Very Much Improved" by week 3 and 6, surpassing the efficacy of celecoxib.

POLIFORCE-2 Capsules come in a convenient packaging of 10 x 10 capsules, ensuring a sufficient supply for extended use. Intra Life is committed to providing top-quality healthcare solutions, backed by extensive research and clinical evidence.

What is osteoarthritis?

Osteoarthritis is a chronic condition that causes pain, stiffness, and inflammation in the joints. It is the most common form of arthritis, affecting millions of people worldwide.

What makes POLIFORCE-2 different from other NSAIDs?

POLIFORCE-2 is a tissue-specific drug that targets affected joints, while simultaneously preserving the integrity of your GI and CV systems. This means that you can get the pain relief you need without the risk of serious side effects.

POLIFORCE-2 has a novel dual mode of action. It inhibits COX-2, the enzyme that produces inflammation, and it binds to carbonic anhydrase, an enzyme that is involved in pain transmission. This dual mode of action provides more effective pain relief than traditional NSAIDs.

POLIFORCE-2 has a long half-life, so you only need to take it once a day. This makes it easy to remember to take your medication and helps to ensure that you get the relief you need throughout the day.

Clinical trials have shown that POLIFORCE-2 is effective in relieving pain and inflammation in people with osteoarthritis.

In a clinical trial, patients who took POLIFORCE-2 reported their condition as "Much Improved" or "Very Much Improved" by week 3 and 6 as compared to patients who took celecoxib.

POLIFORCE-2 is now available in India.

If you are looking for a safe and effective way to relieve the pain and inflammation of osteoarthritis, talk to your doctor about POLIFORCE-2.

Here are some of the benefits of POLIFORCE-2:

  • Provides rapid relief from pain and inflammatio
  • Preserves the integrity of your GI and CV systems
  • Has a novel dual mode of action
  • Only needs to be taken once a day
  • Has been shown to be effective in clinical trials

Who should take POLIFORCE-2?

POLIFORCE-2 is a safe and effective option for people with osteoarthritis who are looking for relief from pain and inflammation. It is especially well-suited for people who are at risk for GI or CV side effects from other NSAIDs.

How to take POLIFORCE-2?

The recommended dose of POLIFORCE-2 is 2 mg once daily. You should take it with food to reduce the risk of stomach upset.

What are the side effects of POLIFORCE-2?

The most common side effects of POLIFORCE-2 are headache, nausea, and upset stomach. These side effects are usually mild and go away on their own.

Is POLIFORCE-2 safe?

POLIFORCE-2 is a safe and effective drug for most people. However, it is important to talk to your doctor before taking POLIFORCE-2 if you have any health conditions, such as liver or kidney disease.

Manufacturing & Properties

Manufacturing

POLIFORCE-2 capsules are manufactured by Intra Life Private Limited, a pharmaceutical company based in India. The capsules are manufactured in a GMP-certified facility, which means that they have been produced according to strict quality standards. The manufacturing process involves a number of steps, including:

  • Preparation of the active ingredient: The active ingredient in POLIFORCE-2 capsules is polmacoxib. Polmacoxib is synthesized in a series of chemical reactions.
  • Formulation of the capsules: The active ingredient is then formulated into capsules. The capsules are made of a gelatin shell and contain a powder that contains the active ingredient.
  • Packaging of the capsules: The capsules are then packaged in blister packs or bottles. The blister packs or bottles are then labeled with the product information.

Properties

POLIFORCE-2 capsules contain the active ingredient polmacoxib, which is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs work by reducing inflammation and pain. POLIFORCE-2 capsules also have a novel dual mode of action, meaning that they work in two different ways to provide pain relief. First, they inhibit COX-2, an enzyme that is involved in inflammation. Second, they bind to carbonic anhydrase, an enzyme that is involved in pain transmission.

The dual mode of action of POLIFORCE-2 capsules makes them a more effective pain reliever than traditional NSAIDs. Traditional NSAIDs only inhibit COX-2, which can lead to side effects such as stomach upset and ulcers. POLIFORCE-2 capsules, on the other hand, also bind to carbonic anhydrase, which helps to reduce the risk of these side effects.

Dosage

The recommended dosage of POLIFORCE-2 capsules is 2 mg once daily. You should take it with food to reduce the risk of stomach upset.

Side effects

The most common side effects of POLIFORCE-2 capsules are headache, nausea, and upset stomach. These side effects are usually mild and go away on their own.

Safety

POLIFORCE-2 capsules are a safe and effective drug for most people. However, it is important to talk to your doctor before taking POLIFORCE-2 if you have any health conditions, such as liver or kidney disease.

Conclusion

POLIFORCE-2 capsules are a novel non-steroidal anti-inflammatory drug that is effective in relieving pain and inflammation. They have a dual mode of action, which makes them more effective than traditional NSAIDs and reduces the risk of side effects. POLIFORCE-2 capsules are a safe and effective option for most people, but it is important to talk to your doctor before taking them if you have any health conditions.

Qualitative and Quantitative

Qualitative

The qualitative properties of POLIFORCE-2 capsules include:

  • Appearance: The capsules are white and round.
  • Taste: The capsules have a slightly bitter taste.
  • Solubility: The capsules are soluble in water.
  • Stability: The capsules are stable at room temperature.

Quantitative

The quantitative properties of POLIFORCE-2 capsules include:

  • Active ingredient: The active ingredient in POLIFORCE-2 capsules is polmacoxib. Each capsule contains 2 mg of polmacoxib.
  • Excipients: The excipients in POLIFORCE-2 capsules include gelatin, lactose, and magnesium stearate.
  • Dosage: The recommended dosage of POLIFORCE-2 capsules is 2 mg once daily.
  • Storage: POLIFORCE-2 capsules should be stored at room temperature.

Clinical Particulars

  • Pharmacotherapeutic group: Non-steroidal anti-inflammatory drugs.
  • Indications: POLIFORCE-2 capsules are indicated for the relief of pain and inflammation associated with osteoarthritis.
  • Dosage and administration: The recommended dosage of POLIFORCE-2 capsules is 2 mg once daily. The capsules should be taken with food to reduce the risk of stomach upset.
  • Contraindications: POLIFORCE-2 capsules are contraindicated in patients with:
    • Hypersensitivity to polmacoxib or any of the excipients in the capsules.
    • Active peptic ulcer or active gastrointestinal bleeding.
    • Severe hepatic or renal impairment.
    • Pregnancy and lactation.
  • Warnings and precautions: POLIFORCE-2 capsules should be used with caution in patients with:
    • A history of gastrointestinal bleeding or ulcers.
    • Heart failure.
    • Hypertension.
    • Renal impairment.
    • Hepatic impairment.
    • Concomitant use of other NSAIDs or corticosteroids.
    • Concomitant use of aspirin.
    • Elderly patients.

Adverse reactions: The most common side effects of POLIFORCE-2 capsules are headache, nausea, and upset stomach. These side effects are usually mild and go away on their own. Other side effects that have been reported include:

  • Dizziness.
  • Constipation.
  • Diarrhea.
  • Rash.
  • Pruritus.
  • Edema.
  • Asthenia.
  • Overdose: There have been no reports of overdose with POLIFORCE-2 capsules. However, if you experience an overdose, seek medical attention immediately.
  • Pharmacokinetics: Polmacoxib is well absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after about 1 hour. Polmacoxib is metabolized in the liver and excreted in the urine. The half-life of polmacoxib is about 8 hours.
  • Pharmacodynamics: Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.
  • Preclinical safety data: Preclinical studies have shown that polmacoxib is safe and well-tolerated in animals.
  • Storage: POLIFORCE-2 capsules should be stored at room temperature.

Nonclinical Properties

  • Pharmacodynamic properties: Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.
  • Pharmacokinetic properties: Polmacoxib is well absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after about 1 hour. Polmacoxib is metabolized in the liver and excreted in the urine. The half-life of polmacoxib is about 8 hours.
  • Toxicological properties: Polmacoxib has been shown to be safe and well-tolerated in animals. In toxicity studies, polmacoxib did not cause any significant organ damage. Polmacoxib was also not mutagenic or carcinogenic in animal studies.

The nonclinical properties of POLIFORCE-2 capsules have been studied in a number of animal models. These studies have shown that polmacoxib is a safe and effective drug for the relief of pain and inflammation.

Pharmacodynamic properties: Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.

Pharmacokinetic properties: Polmacoxib is well absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after about 1 hour. Polmacoxib is metabolized in the liver and excreted in the urine. The half-life of polmacoxib is about 8 hours.

Toxicological properties: Polmacoxib has been shown to be safe and well-tolerated in animals. In toxicity studies, polmacoxib did not cause any significant organ damage. Polmacoxib was also not mutagenic or carcinogenic in animal studies.

Safety studies: Polmacoxib has been studied in a number of safety studies in animals. These studies have shown that polmacoxib is safe and well-tolerated in animals at doses up to 100 mg/kg/day. Polmacoxib did not cause any significant organ damage in these studies.

Efficacy studies: Polmacoxib has also been studied in a number of efficacy studies in animals. These studies have shown that polmacoxib is effective in reducing pain and inflammation in animal models of osteoarthritis.

Pharmaceutical Particulars

  • Name of the medicinal product: POLIFORCE-2 capsules
  • Active substance: Polmacoxib
  • Qualitative and quantitative composition: Each capsule contains 2 mg of polmacoxib.
  • Each capsule contains 2 mg of polmacoxib.
  • Excipients: Gelatin, lactose monohydrate, magnesium stearate.
  • Pharmaceutical form: Capsules.
  • Storage: Store at room temperature (25°C).
  • Marketing authorization holder: Intra Life Private Limited.

Pharmacodynamic properties: Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.

Pharmacokinetic properties: Polmacoxib is well absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after about 1 hour. Polmacoxib is metabolized in the liver and excreted in the urine. The half-life of polmacoxib is about 8 hours.

Clinical Particulars: POLIFORCE-2 capsules are indicated for the relief of pain and inflammation associated with osteoarthritis.

Dosage and administration: The recommended dosage of POLIFORCE-2 capsules is 2 mg once daily. The capsules should be taken with food to reduce the risk of stomach upset.

Contraindications: POLIFORCE-2 capsules are contraindicated in patients with:

  • Hypersensitivity to polmacoxib or any of the excipients in the capsules.
  • Active peptic ulcer or active gastrointestinal bleeding.
  • Severe hepatic or renal impairment.
  • Pregnancy and lactation.

Warnings and precautions: POLIFORCE-2 capsules should be used with caution in patients with:

  • A history of gastrointestinal bleeding or ulcers.
  • Heart failure.
  • Hypertension.
  • Renal impairment.
  • Hepatic impairment.
  • Concomitant use of other NSAIDs or corticosteroids.
  • Concomitant use of aspirin.
  • Elderly patients.

Adverse reactions: The most common side effects of POLIFORCE-2 capsules are headache, nausea, and upset stomach. These side effects are usually mild and go away on their own. Other side effects that have been reported include:

  • Dizziness.
  • Constipation.
  • Diarrhea.
  • Rash.
  • Pruritus.
  • Edema.
  • Asthenia.

Overdose: There have been no reports of overdose with POLIFORCE-2 capsules. However, if you experience an overdose, seek medical attention immediately.

Pharmacokinetics: Polmacoxib is well absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after about 1 hour. Polmacoxib is metabolized in the liver and excreted in the urine. The half-life of polmacoxib is about 8 hours.

Pharmacodynamics: Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.

Preclinical safety data: Preclinical studies have shown that polmacoxib is safe and well-tolerated in animals.

Clinical trials: POLIFORCE-2 capsules have been studied in a number of clinical trials. These studies have shown that polmacoxib is effective in reducing pain and inflammation in patients with osteoarthritis.

Other information: POLIFORCE-2 capsules are a prescription drug.

Patient Counselling

What is POLIFORCE-2?

POLIFORCE-2 is a prescription drug that is used to relieve pain and inflammation associated with osteoarthritis. It is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.

How does POLIFORCE-2 work?

POLIFORCE-2 is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the COX-2 enzyme. COX-2 is an enzyme that is involved in inflammation. By inhibiting COX-2, polmacoxib reduces inflammation and pain.

What are the benefits of taking POLIFORCE-2?

POLIFORCE-2 is a safe and effective drug for the relief of pain and inflammation associated with osteoarthritis. It is also well-tolerated by most people.

What are the risks of taking POLIFORCE-2?

Like all drugs, POLIFORCE-2 can have side effects. The most common side effects are headache, nausea, and upset stomach. These side effects are usually mild and go away on their own. Other side effects that have been reported include:

  • Dizziness
  • Constipation
  • Diarrhea
  • Rash
  • Pruritus
  • Edema
  • Asthenia

How should I take POLIFORCE-2?

The recommended dosage of POLIFORCE-2 is 2 mg once daily. The capsules should be taken with food to reduce the risk of stomach upset.

What if I miss a dose of POLIFORCE-2?

If you miss a dose of POLIFORCE-2, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of POLIFORCE-2 at the same time.

What if I overdose on POLIFORCE-2?

If you overdose on POLIFORCE-2, seek medical attention immediately. Overdose can cause serious side effects, including liver damage and kidney damage.

What should I avoid while taking POLIFORCE-2?

You should avoid taking POLIFORCE-2 if you are allergic to polmacoxib or any of the excipients in the capsules. You should also avoid taking POLIFORCE-2 if you have:

  • Active peptic ulcer or active gastrointestinal bleeding
  • Severe hepatic or renal impairment
  • Pregnancy or lactation

What are the other interactions of POLIFORCE-2?

POLIFORCE-2 can interact with other drugs, including:

  • Aspirin
  • Other NSAIDs
  • Corticosteroids
  • Warfarin
  • Lithium

If you are taking any other medications, talk to your doctor before taking POLIFORCE-2.

What should I do if I have side effects from POLIFORCE-2?

If you have any side effects from POLIFORCE-2, talk to your doctor. Most side effects are mild and go away on their own. However, some side effects can be serious. If you have any serious side effects, seek medical attention immediately.

How long should I take POLIFORCE-2?

You should only take POLIFORCE-2 for as long as your doctor prescribes it. If you need to take POLIFORCE-2 for a long time, your doctor will monitor you closely for side effects.

What should I do if I want to stop taking POLIFORCE-2?

If you want to stop taking POLIFORCE-2, talk to your doctor. Do not stop taking POLIFORCE-2 suddenly, as this can cause withdrawal symptoms. Your doctor will help you taper off the medication gradually.

About Intra Life

Intra Life is a leading pharmaceutical company that is dedicated to providing high-quality, innovative supplements that can help people live healthier lives. Intra Life is committed to research and development, and it is constantly working to bring new and improved products to market.

Intra Life latest product POLIFORCE-2, a new non-steroidal anti-inflammatory drug (NSAID) for the relief of pain and inflammation associated with osteoarthritis. POLIFORCE-2 is a novel drug that has a dual mode of action, making it more effective than traditional NSAIDs. The drug is also well-tolerated by most people, making it a safe and effective option for the relief of osteoarthritis pain.

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